AOD-9604 is an artificial peptide fragment of human progress hormone (HGH), consisting of amino acids 176–191. It was developed to seize the fat-burning results of HGH with out the dangers related to progress or insulin signaling. Through the years, it has been studied for weight problems, metabolic problems, and fats loss, and it’s now utilized in wellness and efficiency clinics as a analysis peptide.
On this information, we’ll break down:
→ What AOD-9604 is and why it was developed
→ The way it works to speed up fats metabolism
→ Customary dosage protocols from scientific and experimental settings
→ Cycle lengths and greatest practices
→ Security and unwanted side effects associated to dosing
→ Authorized issues for customers in several areas
What Is AOD-9604?
AOD-9604 is a artificial peptide fragment of human progress hormone (HGH), composed of amino acids 176–191 on the C-terminal finish of the HGH molecule. Researchers found that this particular sequence is liable for a lot of HGH’s fat-burning exercise with out its growth-promoting results.
Why It Was Developed
→ Focused fats loss: Designed to advertise lipolysis (fats breakdown) and inhibit lipogenesis (fats formation).
→ Security benefit: In contrast to HGH, AOD-9604 doesn’t considerably affect IGF-1, insulin sensitivity, or blood sugar regulation (Heffernan, Journal of Endocrinology).
→ Therapeutic potential: Initially investigated as an anti-obesity drug, it has since gained consideration within the wellness and peptide remedy communities for weight reduction and metabolic well being.
Right now, AOD-9604 is out there by way of analysis suppliers and compounding pharmacies, usually used for fats loss protocols in non-FDA-approved settings.
How AOD-9604 Works
AOD-9604 was designed to copy the lipolytic (fat-burning) properties of human progress hormone whereas eradicating its progress and insulin-related exercise. It acts totally on fats metabolism pathways, making it extremely particular in comparison with HGH.
Mechanisms of Motion
→ Stimulates lipolysis: Enhances the breakdown of saved fats into free fatty acids, which may then be used for power (Heffernan, Journal of Endocrinology).
→ Inhibits lipogenesis: Suppresses the enzymes liable for creating new fats tissue, decreasing the physique’s tendency to retailer extra power as fats (Ng, Diabetes, Weight problems and Metabolism).
→ Promotes fats oxidation: Encourages the physique to burn fats as gasoline, particularly together with calorie management and train.
→ No IGF-1 or glucose disruption: In contrast to HGH, AOD-9604 doesn’t considerably improve IGF-1 or negatively have an effect on insulin sensitivity, making it a safer candidate for metabolic regulation (Ng, Diabetes, Weight problems and Metabolism).
AOD-9604 Dosage Protocols
AOD-9604 is often administered by way of subcutaneous injection, although compounded variations in capsules or troches additionally exist. In each scientific analysis and wellness settings, dosing is comparatively constant — low microgram quantities designed for day by day use.
Customary Medical Dosage
→ 200–500 mcg day by day, delivered as a subcutaneous injection within the belly area.
→ Greatest administered within the morning, when fats mobilization is of course increased.
→ Medical trials investigating weight problems used these dosing ranges with favorable security outcomes (Ng, Diabetes, Weight problems and Metabolism).
Experimental / Wellness Protocols
→ 250–500 mcg day by day, injected as soon as per day, is the commonest observe in weight reduction clinics and peptide protocols.
→ Some practitioners suggest splitting the dose into two day by day injections (AM + PM) to take care of regular publicity.
→ Usually paired with eating regimen and train regimens for enhanced fat-loss outcomes.
Oral and Troche Types
→ Obtainable by way of compounding pharmacies, however bioavailability is much less constant than injections.
→ Best outcomes are seen with subcutaneous supply on account of direct absorption.
Cycle Size and Greatest Practices
Since AOD-9604 will not be a growth-promoting hormone and doesn’t elevate IGF-1, its dosing protocols are usually designed for brief to reasonable cycles moderately than steady long-term use.
Typical Cycle Lengths
→ Weight reduction protocols: 4–12 weeks, relying on objectives and response.
→ Medical trial durations: Most weight problems research used day by day dosing for 12 weeks (Ng, Diabetes, Weight problems and Metabolism).
→ Wellness clinic use: Usually structured in 8-week cycles, adopted by reassessment earlier than persevering with.
Greatest Practices
→ Consistency issues: AOD-9604 is simplest when dosed day by day with out skipping, as its results are gradual.
→ Stacking issues: Will be mixed with way of life interventions (calorie deficit, train) and, in some protocols, with different peptides comparable to CJC-1295/Ipamorelin for enhanced metabolic affect.
→ Injection website rotation: Rotate subcutaneous injection websites to scale back irritation.
→ Timing: Morning injections are most popular, aligning with pure circadian fats metabolism.
Sensible Takeaway
AOD-9604 needs to be approached as a supportive remedy — not a standalone fat-loss resolution. Its greatest outcomes are achieved when paired with vitamin, coaching, and constant cycle administration
AOD-9604 Dosing and Biking Overview
| Use Case | Dosage Vary | Frequency | Cycle Size | Notes |
|---|---|---|---|---|
| Medical (weight problems trials) | 200–500 mcg | 1× day by day (subQ) | 12 weeks | Trials confirmed good tolerability and placebo-like facet impact profile (Ng, Diabetes, Weight problems and Metabolism). |
| Wellness / weight reduction clinics | 250–500 mcg | 1× day by day (AM) or cut up AM+PM | 8–12 weeks | Usually mixed with eating regimen + train; reassess after cycle. |
| Athletic / efficiency reducing | 300–500 mcg | 1× day by day (subQ) | 4–8 weeks | Generally stacked with CJC-1295/Ipamorelin, SARMs, or fats burners. |
| Joint/cartilage restore protocols | 200–300 mcg | 1× day by day (subQ) | 4–6 weeks | Investigated for cartilage regeneration; typically paired with BPC-157 or TB-500. |
| Repeat cycles | — | — | After 2–4 week break | Prevents diminishing returns and permits reassessment of outcomes. |
⚡ This desk makes it clear that AOD-9604 is dose-consistent throughout contexts (200–500 mcg), however cycle size and objectives decide the way it’s utilized.
Stacking AOD-9604 with Different Compounds
Whereas AOD-9604 will be run solo for fats loss help, many protocols incorporate it into stacking methods with different peptides or efficiency enhancers to maximise outcomes.
Widespread Peptide Stacks
→ AOD-9604 + CJC-1295/Ipamorelin:
Combining AOD-9604 with progress hormone secretagogues enhances total fats metabolism. CJC-1295 and Ipamorelin stimulate endogenous HGH launch, whereas AOD-9604 targets fats immediately with out affecting IGF-1. This twin motion can speed up fats loss and physique recomposition.
→ AOD-9604 + BPC-157 or TB-500:
For people prioritizing restoration and joint well being alongside fats loss, AOD-9604 could also be paired with therapeutic peptides. That is significantly helpful for athletes reducing weight whereas managing coaching accidents.
With Anabolic Steroids or SARMs
→ Slicing cycles: AOD-9604 is typically added to anabolic or SARM-based reducing protocols (e.g., Anavar, Winstrol, or Cardarine). It supplies extra fats metabolism help with out including hormonal burden.
With Life-style and Dietary supplements
→ Works greatest alongside a calorie-controlled eating regimen, resistance coaching, and cardiovascular train.
→ Will be mixed with non-stimulant fats burners (like L-carnitine) or gentle thermogenics to boost metabolic results.
Key Takeaway
AOD-9604 stacks properly with different fats loss and restoration instruments, however needs to be used strategically — it’s simplest as a supportive compound moderately than the centerpiece of a cycle.
Advantages of AOD-9604
When dosed persistently, AOD-9604 supplies focused fat-burning and metabolic help with out the systemic hormonal dangers seen with full-length HGH.
Fats Loss and Physique Composition
→ Accelerates fats breakdown: Stimulates lipolysis, serving to launch saved fatty acids for power (Heffernan, Journal of Endocrinology).
→ Prevents fats storage: Inhibits lipogenesis, decreasing the physique’s means to retailer new fats (Ng, Diabetes, Weight problems and Metabolism).
→ Targets belly/visceral fats: Medical knowledge suggests exercise in decreasing cussed central fats, which is linked to metabolic danger.
Metabolic Well being
→ Impartial on glucose management: In contrast to HGH, AOD-9604 doesn’t negatively affect insulin sensitivity or fasting blood glucose.
→ Improves lipid metabolism: Some proof factors to higher ldl cholesterol and triglyceride regulation in overweight people.
Joint and Restoration Advantages
→ Cartilage regeneration: Early knowledge suggests attainable joint-protective properties, making it a possible therapeutic candidate for osteoarthritis and cartilage restore (Ng, Diabetes, Weight problems and Metabolism).
Benefits Over Different Fats-Loss Therapies
→ No IGF-1 elevation: Avoids dangers of acromegaly or undesirable tissue progress.
→ Non-stimulant: Appropriate for people delicate to caffeine or thermogenics.
→ Secure profile: Medical trials present AOD-9604 is properly tolerated with a side-effect charge just like placebo.
Aspect Results of AOD-9604
Medical research and wellness use counsel AOD-9604 has a sturdy security profile, particularly when in comparison with HGH or stimulant-based fats burners. Most unwanted side effects are gentle, localized, and transient.
Generally Reported
→ Injection website irritation: Redness, swelling, or itching on the subcutaneous injection website is probably the most frequent situation.
→ Headache or fatigue: Sometimes reported, often resolving with out intervention.
Much less Widespread / Attainable Results
→ Digestive upset (oral/troche types): Some compounded non-injectable variations might trigger gentle gastrointestinal discomfort.
→ Allergic reactions: Uncommon, however attainable with any peptide.
Key Security Differentiators
→ No IGF-1 elevation: AOD-9604 doesn’t stimulate IGF-1, that means it avoids dangers comparable to organ/tissue overgrowth or acromegaly (Heffernan, Journal of Endocrinology).
→ No glucose disruption: Medical knowledge reveals it doesn’t impair insulin sensitivity or worsen blood sugar regulation (Ng, Diabetes, Weight problems and Metabolism).
→ Similar to placebo: In weight problems trials, the incidence of antagonistic results was just like placebo teams, underscoring its tolerability (Ng, Diabetes, Weight problems and Metabolism).
Authorized Standing of AOD-9604
→ United States: AOD-9604 is not FDA-approved as a drug, dietary complement, or weight reduction remedy. It’s obtainable solely by way of analysis chemical suppliers and a few compounding pharmacies, the place it’s typically labeled “not for human use” to adjust to laws (FDA, Medicine@FDA Database).
→ Australia: Categorised as a Schedule 4 prescription-only drugs, that means it might solely be legally obtained with a health care provider’s prescription.
→ European Union & UK: AOD-9604 has no medical approval. Importation and distribution are usually restricted except clearly labeled for laboratory or analysis functions.
→ Sports activities and WADA compliance: AOD-9604 is explicitly included on the World Anti-Doping Company (WADA) Prohibited Checklist, making it banned in all aggressive sports activities no matter dosage or route of administration (WADA, Prohibited Checklist 2025).
Conclusion
AOD-9604 is a specialised HGH fragment designed to ship fat-burning results with out the dangers of progress hormone remedy. At commonplace dosing ranges of 200–500 mcg day by day, it helps lipolysis, fats oxidation, and diminished fats storage, whereas avoiding will increase in IGF-1 or destructive impacts on glucose metabolism.
Cycle lengths usually run 4–12 weeks, relying on objectives:
→ 4–8 weeks for efficiency and reducing phases.
→ 8–12 weeks for wellness and clinical-style fats loss.
→ 4–6 weeks for joint/cartilage help protocols.
Greatest outcomes come when AOD-9604 is mixed with eating regimen, train, and stacking methods comparable to CJC-1295/Ipamorelin or restoration peptides like BPC-157. Its facet impact profile is mostly gentle, with most customers reporting solely injection website irritation or fatigue.
Legally, AOD-9604 stays unapproved by the FDA and is banned in aggressive sports activities below WADA pointers, although it’s obtainable by way of compounding pharmacies and analysis suppliers.
Backside line: AOD-9604 affords a focused, non-stimulant strategy to fats loss and metabolic help — greatest suited as a supportive remedy, not a standalone resolution.
⚠️ Disclaimer: This content material is for academic and informational functions solely and doesn’t represent medical recommendation. AOD-9604 will not be authorized by the FDA for fats loss or therapeutic use. At all times seek the advice of a certified healthcare skilled earlier than beginning, stopping, or combining any complement, peptide, or medicine.
AOD-9604 Dosage Information — FAQ
How do you’re taking AOD-9604?
The commonest methodology is subcutaneous injection, usually into the belly area. Customary dosing ranges from 200–500 mcg as soon as day by day, although some protocols cut up the dose AM and PM for regular publicity (Ng, Diabetes, Weight problems and Metabolism).
How lengthy ought to an AOD-9604 cycle final?
Typical cycles run 4–12 weeks, relying on objectives. Efficiency athletes typically use 4–8 weeks for reducing, whereas wellness protocols final 8–12 weeks. Medical trials for weight problems examined 12-week cycles.
Do you might want to cycle off AOD-9604?
Sure. Most protocols suggest a 2–4 week break after a cycle to reassess progress and forestall diminishing returns.
Are you able to stack AOD-9604 with different peptides?
Sure. Widespread stacks embrace:
→ CJC-1295/Ipamorelin for synergistic fats metabolism.
→ BPC-157 or TB-500 for joint and tissue restore.
→ Anavar or SARMs (reducing cycles) for physique enhancement.
What are the principle unwanted side effects?
Uncomfortable side effects are usually gentle — most frequently injection website irritation, fatigue, or headache. In contrast to HGH, AOD-9604 doesn’t considerably have an effect on IGF-1 or blood sugar (Heffernan, Journal of Endocrinology).
Is AOD-9604 authorized?
→ United States: Not FDA-approved; obtainable by way of analysis suppliers and a few compounding pharmacies.
→ Australia: Schedule 4 prescription-only drugs.
→ Sports activities: Explicitly banned by WADA in aggressive athletics (WADA, Prohibited Checklist 2025).